Latest Mesothelioma Treatments
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Chemotherapy: Single Agent
Mesothelioma is quite resistant to drugs with the
majority of single chemotherapeutic agents not
only having significant toxicities but also
showing response rates below 20%.
There is no single drug that appears to have an impact
on overall survival, the single agents listed here
suggest they are the most active against
mesothelioma:
- 5-fluorouracil,
- methotrexate (high dose),
- timetrexate,
- doxorubicin,
- epirubicin,
- cyclophosphamide,
- ifosfamide,
- mitomycin C,
- Platinol® (cisplatin),
- interferon, and
- Alimta®.
Vinorelbine has also been suggested as providing relief of
symptoms with low toxicity.
Cisplatin is the widely established measure mesothelioma
single agent treatment but Alimta® (pemetrexed) has
been hailed as a "major step forward in the treatment of
mesothelioma" having a reported response rate of 16%
when evaluated as a single agent drug in a phase II trial
in the United States, Italy and Germany.
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